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MYD88 Mutation Testing

 

Background

The MYD88 p.(Leu265Pro) mutation has been indicated to be the hallmark change in patients with Waldenstrom macroglobulinemia (WM). This mutation is also reported in patients with splenic marginal zone lymphoma (SMZL) and in other B-cell chronic lymphoproliferative disorders.
 

Testing at WRGL

Amplification specific Polymerase Chain Reaction (AS-PCR) using two sets of fluorescent primers are used to perform this testing. The PCR product can be visualised using GeneMapper software following fragment analysis on the 3130. Genetic Analyser. Positive and negative controls are included in each reaction.

 

Cost, Sample Requirements & Turnaround Times

 

Test

Cost NZD*

Sample Requirements

Current TAT

MYD88
p.(Leu265Pro) Mutation testing
$203 1 ml of bone marrow or  2x4ml of whole blood (if malignant cells are circulating in peripheral blood) in EDTA 

1 week

For urgent cases please contact the laboratory

 
*No direct charge for the central region DHBs covered by the Crown Funding Agreement

MYD88 mutation testing

ABOUT US

Wellington Regional Genetics Laboratory (WRGL) provides a comprehensive, integrated diagnostic cytogenetic and molecular genetic testing service

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CONTACT US

(04) 918-5352
wrgl@ccdhb.org.nz