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Genetics-05-290WgtnGS-33-325Scanner-122-15-454

Cost of FISH NZD $508 per Test*

*No direct charge for the central region DHBs covered by the Crown Funding Agreement

Oncology FISH Tests                         Solid Tumour FISH Tests                       Postnatal & Prenatal FISH Tests    

For specific FISH specimen requirements please click here   

 

Myeloid Disorders

Lymphoid/Mature B-cell Neoplasms

Mature B-cell Neoplasms/Mature T-cell Neoplasms

Myeloproliferative Neoplasms

BCR/ABL1 rearrangement - t(9;22)
Loss of 7q31 and 7q22
Trisomy 8
Trisomy 9
Loss of D13S319/LAMP1 (13q14/13q34)
Loss of 20q

 

Adult Acute Lymphoid Leukaemia (ALL)

BCR/ABL1 rearrangement - t(9;22)
Hyperdiploidy/near haploidy
KMT2A (MLL) rearrangement (11q23)
IGH rearrangement (14q32)
Loss of 9p (CDKN2A)
Deletions of 6q (MYB)
NUP98 rearrangements (11p15) (T-ALL)
ABL1 amplification (T-ALL)
MEF2D rearrangement (1q22)

Marginal Zone B-Cell Lymphoma, Splenic

MALT1 rearrangement (18q21)
Loss of 7q31 and 7q22
Gain of 3q27
Gain of chromosome 12
Loss of TP53 (17p13.1)
BCL6 rearrangement (3q27)

Myeloid/Lymphoid Neoplasms with Eosinophilia and Gene Rearrangement

PDGFRA rearrangement (4q12)
PDGFRB rearrangement (5q33)
FGFR1 (8p11.2)
JAK2 rearrangement (9p24.1)

Childhood Acute Lymphoid Leukaemia (ALL)

KMT2A (MLL) rearrangement (11q23)
RUNX1/ETV6 rearrangement- t(12;21)
BCR/ABL1 rearrangement- t(9;22)
Hyperdiploidy/near haploidy
iAMP(21)
IGH rearrangement (14q32)
Loss of 9p (CDKN2A)
Deletions of 6q (MYB)
ABL1 amplification (T-ALL)
MEF2D rearrangement (1q22)
TCF3/PBX1/HLF rearrangements (19p13,1q23,17q22)

Lymphoplasmacytic Lymphoma

IGH rearrangement (14q32)
Loss of MYB (6q23)

 

Myelodysplastic Syndrome

MECOM (EVI1) rearrangement (3q26.2)
Monosomy 5 or loss of 5q31
Monosomy 7 or loss of 7q31 and 7q22
Trisomy 8
Loss of 9q
Loss of 20q
NUP98 rearrangements (11p15)

Chronic Lymphocytic Leukaemia/Small Lymphocytic

Lymphoma

 

Typical Probe:

Loss of TP53 (17p13.1)
 

Full Panel (available on request)

Loss of ATM    (11q22.3)
Loss of TP53   (17p13.1)
Loss of D13S319/LAMP1    (13q14/13q34)
Trisomy 12

Additional Probes Available:

IGH/CCND1 rearrangement -t(11;14) to exclude mantle cell
IGH rearrangement (14q32)
Deletions of 6q (MYB)

Burkitt Lymphoma

MYC rearrangement (8q24)
MYC/IGH rearrangement - t(8;14)
IGK/IGL/MYC rearrangements - t(2;8) or t(8;22)



 

Acute Myeloid Leukaemia (AML)

MECOM (EVI1) rearrangement (3q26.2)
RUNX1T1/RUNX1 rearrangement - t(8;21)
PML/RARA rearrangement - t(15;17)
RARA rearrangement (17q21)
CBFB rearrangement - t(16;16) or inv(16)
KMT2A (MLL) rearrangement (11q23)
Monosomy 5 or loss of 5q31
Monosomy 7 or loss of 7q31 and 7q22
Loss of 9q
NUP98 rearrangements (11p15)
DEK/NUP214 rearrangement - t(6;9)

 


 

Diffuse Large B-Cell Lymphoma with MYC and BCL2 Rearrangements

MYC rearrangement (8q24)
BCL2 rearrangement (18q21)
BCL6 rearrangement (3q27)
IGH rearrangement (14q32)

 

Secondary AML

KMT2A (MLL) rearrangement (11q23)
Monosomy 5 or loss of 5q31
Monosomy 7 or loss of 7q31 and 7q22
MECOM (EVI1) rearrangement (3q26.2)
 

Myeloma/ Plasma Cell Leukaemia

Typical Probe Set:

Loss of TP53 (17p13.1)
Loss of 13q14
IGH rearrangement (14q32)

Additional Probes Available:

IGH/FGFR3 rearrangement - t(4;14)
IGH/MAF rearrangement - t(14;16)
IGH/CCND1-XT rearrangement - t(11;14)
IGH/MAFB rearrangement - t(14;20)
MYC rearrangement (8q24)
Amplification of 1q21(CKS1B)/deletion of 1p (CDKN2C)
Hyperdiploidy panel
Deletions of 6q (MYB)

Anaplastic Large Cell Lymphoma

ALK rearrangement - (2p23)
 

CML

BCR/ABL1 rearrangement - t(9;22)
TP53 - Loss of 17p/i(17)(q10)
Trisomy 8
Trisomy 9
MECOM (EVI1) rearrangement (3q26.2)
NUP98 rearrangements (11p15)

Follicular Lymphoma

BCL2 rearrangement (18q21)
BCL6 rearrangement (3q27)
MYC rearrangement (8q24)
IGH/BCL2 rearrangement - t(14;18)
MYC/IGH rearrangement - t(8;14)
Deletions of 6q (MYB)

Adult T-cell Leukaemia/Lymphoma (ATLL)

TRA/TRD rearrangement (14q11)
TRB rearrangement (7q34)

 
 

Mantle Cell Lymphoma

IGH/CCND1 rearrangement - t(11;14)
CCND2 rearrangement (12p13)

T-cell Prolymphocytic Leukaemia (T-PLL)

TRA/TRD rearrangement (14q11)
TRB rearrangement (7q34)

Post Bone Marrow Transplant

Donor vs recipient (sex mismatch FISH).
FISH for any previously identified abnormality.

 

Diffuse Large B-Cell Lymphoma

BCL2 rearrangement (18q21)
BCL6 rearrangement (3q27)
MYC rearrangement (8q24)
IGH/BCL2 rearrangement - t(14;18)
MYC/IGH rearrangement - t(8;14)
Deletions of 6q (MYB)
Loss of TP53 (17p13.1)
IGK/IGL/MYC rearrangements - t(2;8) or t(8;22)

T-Cell Lymphoma

TRA/TRD rearrangement (14q11)
TRB rearrangement (7q34)

 
 

MALT (Mucosa-Associated Lymphoid Tissue)

MALT1 rearrangement (18q21)		  
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Solid Tumour FISH Tests

 

Central Nervous System Tumours

Soft Tissue Malignancy

Other

High-Grade Glioma / Glioblastoma Multiforme

Loss of 1p / 19q
Amplification of EGFR (7p12)
Loss of 9p  (CDKN2A)

Atypical Lipomatous Tumour / Well-Differentiated liposarcoma

MDM2 amplification (12q15)

 

Breast Cancer

Amplification of ERBB2 (HER2)(17q11.2-q12)

Breast Cancer Secretory

ETV6 rearrangement (12p13)

Low-Grade Glioma / Oligodendroglioma

Loss of 1p / 19q
Loss of 9p  (CDKN2A)
 

Clear Cell Sarcoma / Desmoplastic Small Round Cell

EWSR1 rearrangement (22q11)

Gastric Cancer

Amplification of ERBB2 (HER2)(17q11.2-q12)
Amplification of EGFR (7p12)

Medulloblastoma

Amplification of MYC (8q24)
Amplification of MYCN (2p24)
Imbalance of 17q or i(17q)
Loss of 6q

Dedifferentiated Liposarcoma

MDM2 amplification (12q15)

 

Germ Cell Tumour

Imbalance of 12p or i(12p)

Meningioma

Loss of 22
Loss of 9p (CDKN2A)
 

Ewing's Sarcoma/PNET/Askin's Tumour

EWSR1 rearrangement (22q12)
 

Lung Cancer/Adenocarcinoma

Amplification of EGFR (7p12)
Amplification of ERBB2  (HER2)(17q11.2-q12)
ALK rearrangement (2p23)
ROS1 rearrangement (6q22)


 

Extraskeletal Chrondrosarcoma

EWSR1 rearrangement (22q12)

Squamous Cell Carcinoma of Head & Neck

CCND1 amplification (11q13)

Neuroblastoma

Amplification of MYCN (2p24)
Loss of 1p
Loss of 11q
17p/17q

Infantile Fibrosarcoma

ETV6 rearrangement (12p13)

 

Uveal Melanoma

Monosomy 3
Loss of 9p (CDKN2A)
 

Inflammatory Myofibroblastic Tumour

ALK rearrangement (2p23)

Congenital Mesoblastic Nephroma

EWSR1 rearrangement (22q12)
 

Myxoid Liposarcomas

t(12;16)(q13;p11) (DDIT3 rearrangement)
EWSR1 rearrangement (22q12)

Renal Cell Chromophobe / Oncocytoma

Loss of chromosome 2
Loss of chromosome 10
Loss of chromosome 17
 

Pleomorphic Liposarcomas

MDM2 amplification (12q15)

Renal Papillary Cell Carcinoma

Gain of chromosome 7
Gain of chromosome 17
 

Rhabdomyosarcoma Alveolar

FOXO1 rearrangement (13q14)
 

Transitional Cell Carcinoma

Gain of chromosome 7
Gain of chromosome 9
Gain of chromosome 17
 

Synovial Sarcoma

SS18 rearrangement (18q11.2)

X Translocation Renal Cell Carcinoma

TFE3 rearrangement (Xp11.2)
 
 

Alveolar Soft Part Sarcoma

TFE3 rearrangement (Xp11.2)
 

Nodular Fasciitis

USP6 rearrangement (17p13)
 

Dermatofibrosarcoma protuberans (DFSP)

t(17;22) COL1A/PDGFB rearrangement
 		  
 

Solitary Fibrous Tumour

STAT6 Rearrangement (12q13)		  
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Postnatal and Prenatal FISH Tests

 

FISH Tests by Chromosome

Chromosome 1

1p36 microdeletion syndrome
Whole chromosome paint
Centromere (D1Z5)
Sub-telomeric probes (1p/1q)
1q21.2 microdeletion/microduplication syndromes
1q44 microdeletion syndrome

Chromosome 2

2q37 microdeletion (Albright like syndrome)
Whole chromosome paint
Centromere (D2Z1)
Sub-telomeric probes (2p/2q)

Chromosome 3

Whole chromosome paint
Centromere (D3Z1)
Sub-telomeric probes (3p/3q)

Chromosome 4

Wolf-Hirschorn syndrome (4p16)
Whole chromosome paint
Centromere (D4Z1)
Sub-telomeric probes (4p/4q)

Chromosome 5

Cri-du-Chat syndrome (5p15)
Whole chromosome paint
Centromere (D5Z2)
Sub-telomeric probes (5p/5q)

Chromosome 6

Whole chromosome paint
Centromere (D6Z1)
Sub-telomeric probes (6p/6q)
 

Chromosome 7

7q11.23 microdeletion (Williams syndrome)/microduplication syndrome
Whole chromosome paint
Centromere (D7Z1)
Sub-telomeric probes (7p/7q)

Chromosome 8

8q24 microdeletion
(trichorhinophalangeal syndrome)
Whole chromosome paint
Centromere (D8Z2)
Sub-telomeric probes (8p/8q)

Chromosome 9

Whole chromosome paint
Centromere (chr 9)
Sub-telomeric probes (9p/9q)
 

Chromosome 10

Whole chromosome paint
Centromere (chr 10)
Sub-telomeric probes (10p/10q)

Chromosome 11

Whole chromosome paint
Centromere (D11Z1)
Sub-telomeric probes (11p/11q)

Chromosome 12

Whole chromosome paint
Centromere (D12Z3)
Sub-telomeric probes (12p/12q)

Chromosome 13

13q14 microdeletion syndrome(Retinoblastoma)
Whole chromosome paint
Centromere (D13Z1)
Sub-telomeric probe (13q)
 

Chromosome 14

Whole chromosome paint
Centromere (D14Z1)
Sub-telomeric probe (14q)
 

Chromosome 15

15q11q13 microdeletion (Prader-Willi/Angelman syndrome)
15q13.3 microdeletion/microduplication syndromes
Whole chromosome paint
Centromere (D15Z1)
Sub-telomeric probe (15q)

Chromosome 16

16p11.2 microdeletion/microduplication syndromes
16p12.1 microdeletion/microduplication syndromes
16p13.33 microdeletion/microduplication syndromes
Whole chromosome paint
Centromere (D16Z3)
Sub-telomeric probes (16p/16q)
 

Chromosome 17

17p13.3 microdeletion (isolated lissencephaly and Miller-Dieker syndrome)/microduplication syndrome
17p11.2 microdeletion syndrome (Smith-Magenis)/microduplication syndrome (Potocki-Lupski)
17q12 microdeletion/microduplication syndromes
17q21.31 microdeletion/microduplication syndromes
17p13.1 microdeletion syndrome (Li-Fraumeni)
Whole chromosome paint
Centromere (D17Z1)
Sub-telomeric probes (17p/17q)

Chromosome 18

Whole chromosome paint
Centromere (D18Z1)
Sub-telomeric probes (18p/18q)
 

Chromosome 19

Whole chromosome paint
Centromere (chr 19)
Sub-telomeric probes (19p/19q)
 

Chromosome 20

Whole chromosome paint
Centromere (D20Z1)
Sub-telomeric probes (20p/20q)
 

Chromosome 21

Whole chromosome paint
21q22.13q22.2 locus specific probe
Centromere (chr 21)
Sub-telomeric probe (21q)

Chromosome 22

22q11.2 microdeletion (DiGeorge syndrome)/duplication syndrome
Distal 22q11.2 microdeletion/duplication syndromes
22q13 microdeletion/microduplication syndromes
Whole chromosome paint
Centromere (chr 22)
Sub-telomeric probe (22q)
 

X Chromosome

Xp22.3 deletion syndrome (Kallman)
Xp22.3 deletion (Steroid Sulfatase deficiency syndrome)
Xp22 deletion (SHOX)
Centromere (DXZ1)
Xq13 XIST
Whole chromosome paint
Xq26.2 microdeletion (Simpson-Golabi-Behmel syndrome)
Sub-telomeric probes (Xp/Xq)
M-BAND

Y Chromosome

Yp11.3 (SRY)
Whole chromosome paint
Centromere (DYZ3)
Sub-telomeric probes (Yp/Yq)
 

MFISH (24Cyte)

Simultaneous investigation of all chromosomes

 

Vysis AneuVysion Probe Set for Detection of Aneuploidy

Chromosomes 13, 18, 21, X and Y
 

Custom FISH Probes

FISH probes can be designed for most genes/regions of interest. This can be done for the same price as our routine FISH testing. Please enquire.
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FISH Test List

ABOUT US

Wellington Regional Genetics Laboratory (WRGL) provides a comprehensive, integrated diagnostic cytogenetic and molecular genetic testing service

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CONTACT US

(04) 918-5352
wrgl@ccdhb.org.nz

Please note that genetic test results are only released directly to the referring clinician and not to patients